Publications

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2017

Wilfred Ngwa, Francis Boateng, Rajiv Kumar, Darrell J. Irvine, Silvia Formenti, Twalib Ngoma, Carsten Herskind, Marlon R. Veldwijk, Georg Lars Hildenbrand (2017). Smart Radiation Therapy Biomaterials. Int. J. Radiat. Oncol. 97(3): 624-637. doi:10.1016/j.ijrobp.2016.10.034

Yiran Zheng, Li Tang, Llian Mabardi, Sudha Kumari, and Darrell J. Irvine (2017). Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors. ACS Nano. 11(3): 3089–3100. doi:10.1021/acsnano.7b00078

Jiahe Li, Wade Wang, Yanpu He, Yingzhong Li, Emily Z. Yan, Ketian Zhang, Darrell J. Irvine, and Paula T. Hammond (2017). Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. ACS Nano. 11(3): 2531–2544. doi:10.1021/acsnano.6b08447

R. Brad Jones, Stephanie Mueller, Sudha Kumari, Vlad Vrbanac, Shy Genel, Andrew M. Tager, Todd M. Allen, Bruce D. Walker, Darrell J. Irvine (2017). Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 117: 44-53. doi:10.1016/j.biomaterials.2016.11.048

Yu-Sang Sabrina Yang, Prabhani U. Atukorale, Kelly D. Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci & Darrell J. Irvine (2017). High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry. Nat. Commun. 8: 14069 doi:10.1038/ncomms14069

2016

Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader (2016). Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat. Commun. 7: 13894 doi:10.1038/ncomms13894

Alice Tzeng, Monique J. Kauke, Eric F. Zhu, Kelly D. Moynihan, Cary F. Opel, Nicole J. Yang, Naveen Mehta, Ryan L. Kelly, Gregory L. Szeto, Willem W. Overwijk, Darrell J. Irvine, K. Dane Wittrup (2016). Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy. Cell Reports. 17(10): 2503-2511. doi:10.1016/j.celrep.2016.11.020

Kelly D Moynihan, Cary F Opel, Gregory L Szeto, Alice Tzeng, Eric F Zhu, Jesse M Engreitz, Robert T Williams, Kavya Rakhra, Michael H Zhang, Adrienne M Rothschilds, Sudha Kumari, Ryan L Kelly, Byron H Kwan, Wuhbet Abraham, Kevin Hu, Naveen K Mehta, Monique J Kauke, Heikyung Suh, Jennifer R Cochran, Douglas A Lauffenburger, K Dane Wittrup, and Darrell J Irvine (2016). Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat. Med. doi:10.1038/nm.4200

Hok Hei Tam, Mariane B. Melo, Myungsun Kang, Jeisa M. Pelet, Vera M. Ruda, Maria H. Foley, Joyce K. Hue, Sudha Kumari, Jordan Crampton, Alexis D. Baldeon, Rogier W. Sanders, John P. Moore, Shane Crotty, Robert Langer, Daniel G. Anderson, Arup K. Chakraborty, and Darrell J. Irvine (2016). Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Proc. Natl. Acad. Sci. U.S.A. doi:10.1073/pnas.1606050113

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR (2016). HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity. 45(3): 483–496. doi:10.1016/j.immuni.2016.08.016

Erin Janssen, Mira Tohme, Mona Hedayat, Marion Leick, Sudha Kumari, Narayanaswamy Ramesh, Michel J. Massaad, Sumana Ullas, Veronica Azcutia, Christopher C. Goodnow, Katrina L. Randall, Qi Qiao, Hao Wu, Waleed Al-Herz, Dianne Cox, John Hartwig, Darrell J. Irvine, Francis W. Luscinskas, Raif S. Geha (2016). A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J. Clin. Invest. doi:10.1172/JCI85774

Luke R. Doniusa, Yuxing Cheng, Jaewon Choi, Zhen-Yu J. Sun, Melissa Hanson, Michael Zhang, Todd M. Gierahn, Susanna Marquez, Mohammed Uduman, Steven H. Kleinstein, Darrell Irvine, J. Christopher Love, Ellis L. Reinherz, Mikyung Kim (2016). Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. J. Virol. 90(19): 8875–8890. doi:10.1128/JVI.01089-16

R. Brad Jones, Stefanie Mueller, Rachel O’Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, Bruce D. Walker (2016). A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathogens, 12(4): e1005545. doi:10.1371/journal.ppat.1005545

Darrell J. Irvine (2016). A Receptor for All Occasions. Cell. 164(4): 599-600. doi:10.1016/j.cell.2016.01.030

Darrell J. Irvine (2016). Materializing the future of vaccines and immunotherapy. Nat. Rev. Mater. 1: 15008. doi:10.1038/natrevmats.2015.8

Kimmerling, R., Szeto, G. L., Li, J., Genshaft, A., Kazer, S., Borrajo, J., Blainey, P., Irvine, D. J., Shalek, A., Manalis, S.R. (2016). A microfluidic platform enabling single cell RNA-seq of multigenerational lineages. Nature Communications, 7. doi:10.1038/ncomms10220

2015

Dane, E. L., & Irvine, D. J. (2015). Big thinking for adjuvants. Nature Biotechnology, 33(11), 1146–1148. doi:10.1038/nbt.3398

Arnold, K. B., Szeto, G. L., Alter, G., Irvine, D. J., & Lauffenburger, D. A. (2015). CD4+ T cell–dependent and CD4+ T cell–independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Science Signaling, 8(399), ra104. http://doi.org/10.1126/scisignal.aab0808
Featured on the cover: http://stke.sciencemag.org/content/8/399

Hotaling, N. A., Tang, L., Irvine, D. J., & Babensee, J. E. (2015). Biomaterial Strategies for Immunomodulation. Annual Review of Biomedical Engineering, 17(1), 317–349. http://doi.org/10.1146/annurev-bioeng-071813-104814

Darrell J. Irvine and Hidde Ploegh, "Editorial overview: Special section: Immunological engineering,"Current Opinion in Immunology, 35:ix–xi (2015). http://doi.org/10.1016/j.coi.2015.07.010

Irvine, D. J., Hanson, M. C., Rakhra, K., & Tokatlian, T. (2015). Synthetic Nanoparticles for Vaccines and Immunotherapy. Chemical Reviews, 115(19), 11109–11146. http://doi.org/10.1021/acs.chemrev.5b00109 Pubmed Central Journal in process

B. Huang, W. D. Abraham, Y. Zheng, S. C. Bustamante López, S. S. Luo, D. J. Irvine, "Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells," Sci. Transl. Med. 7, 291ra94 (2015). Cover story with a commentary "Prescription for a pharmacyte" from Jeffrey Hubbell. Pubmed Central Journal in process

Prabhani Atukorale, Yu Sang Yang, Ahmet Bekdemir, Randy Carney, Paulo Silva, Nicki Watson, Francesco Stellacci and Darrell J. Irvine, "Influence of the Glycocalyx and Plasma Membrane Composition on Amphiphilic Gold Nanoparticle Association with Erythrocytes," Nanoscale DOI: 10.1039/C5NR01355K (2015). Pubmed Central Journal in process

Gregory Lee Szeto, Debra Van Egeren, Hermoon Worku, Armon Sharei, Brian Alejandro, Clara Park, Kirubel Frew, Mavis Brefo, Shirley Mao, Megan Heimann, Robert Langer, Klavs Jensen & Darrell J Irvine, "Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines," Scientific Reports, 5 (10276) http://doi.org/10.1038/srep10276 (2015)Pubmed Central

Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, and Irvine DJ, “Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants,” Journal of Clinical Investigation doi:10.1172/JCI79915 (2015). Pubmed Central Journal – in process

Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, and Wittrup KD, “Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2,” Cancer Cell 27(4) 489–501 (2015). Pubmed Central Journal – in process

Liu H and Irvine DJ, “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications,” Bioconjugate Chemistry (DOI: 10.1021/acs.bioconjchem.5b00103), in press

Shenshen Wang,Jordi Mata-Fink,Barry Kriegsman, Melissa Hanson, Darrell J. Irvine, Herman N. Eisen, Dennis R. Burton, K. Dane Wittrup, Mehran Kardar, Arup K. Chakraborty. "Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies," Cell, 160 (4), 785-797, (2015). Pubmed Central Journal in process

Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin. "Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway," eLife 2015;4:e04953.  Pubmed Central Journal in process

Melissa C. Hanson, Wuhbet Abraham, Monica P. Crespo, Stephanie H. Chen, Haipeng Liu, Greg Lee Szeto, Mikyung Kim, Ellis L. Reinherz, Darrell J. Irvine, "Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides," Vaccine, 33 (7), 861-868, (2015). Pubmed Central Journal in process

 

2014

Yang Y-S, Carney RP, Stellacci F, and Irvine DJ, “Enhancing Radiotherapy by Lipid Nanocapsule-Mediated Delivery of Amphiphilic Gold Nanoparticles to Intracellular Membranes,” ACS Nano, 2014, 8 (9), pp 8992–9002. Pubmed Central Journal – in process

Jones RB, O’Connor R, Mueller S, Foley M, Szeto GS, Karel D, Lichterfeld M, Kovacs C, Ostroski MA, Tocha A, Irvine DJ, and Walker BD, “Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes,” PLoS Pathogens 10(8) e1004287 (2014). Pubmed Central Journal – in process

Pejawar-Gaddy S, Kovacs JM, Barouch DH, Chen B, and Irvine DJ, “Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination,” Bioconjugate Chem., 2014, 25 (8), pp 1470–1478. Pubmed Central Journal – in process

Castellarnau M, Szeto GL, Su H-W, Tokatlian T, Love JC, Irvine DJ, and Voldman J “Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis,” Small DOI: 10.1002/smll.201401369. Pubmed Central Journal – in process

Hanson MC, Bershteyn A, Crespo MP, and Irvine DJ, “Antigen Delivery by Lipid-enveloped PLGA Microparticle Vaccines Mediated by in situ Vesicle Shedding,” Biomacromolecules 15 2475-2481 (2014). Pubmed Central Journal – in process

Liu H, Moynihan K, Zheng Y, Szeto G, Li A, Huang B, Egeren D, Park C, Irvine D. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 507(7493): 519–522 (2014). PMID: 24531764. Pubmed Central Journal – in process

Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, and Irvine DJ, "High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function," PLoS ONE 9 e87873 (2014). Pubmed Central Journal – in process

DeMuth PC, Min Y, Irvine DJ, and Hammond PT, "Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization," Advanced Healthcare Materials 3(1) 47-58 (2014). PMCID: PMC3950936

 

2013

DeMuth PC, Li AV, Abbink P, Liu J, Li H, Stanley KA, Smith KM, Lavine CL, Seaman MS, Kramer JA, Miller AD, Abraham W, Suh H, Elkhader J, Hammond PT, Barouch DH, and Irvine DJ, "Vaccine delivery with microneedle skin-patches in nonhuman primates," Nature Biotechnology 31 1082-1085 (2013). PMCID: PMC4011140.

Irvine DJ, Swartz MA, and Szeto GL, "Engineering synthetic vaccines using cues from natural immunity," Nature Materials 12(11) 978-990 (2013). PMCID: PMC3928825.

Li AV, Moon JJ, Abraham W, Suh H, Elkhader J, Seidman MA, Yen M, Im EJ, Foley MH, Barouch DH, and Irvine DJ, "Generation of effector memory T-cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination," Science Translational Medicine 5 204ra130 (2013). PMCID: PMC3934930.

Drake A, Joshi NS, Szeto GL, Zhu EF, Eisen HN, and Irvine DJ, "Koch Institute symposium on cancer immunology and immunotherapy," Cancer Immunology Research 1(4) 217-222 (2013). PMCID: PMC3897860.

Kim M, Song L, Moon J, Sun Z-YJ, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine D, and Reinherze E, "Immunogenicity of membrane-bound HIV-1 gp41 MPER segments is dominated by residue accessibility and modulated by stereochemistry," Journal of Biological Chemistry 288:31888-31901 (2013). PMCID: PMC3814781.

Van Lehn RC, Atukorale PU, Carney RP, Yang YS, Stellacci F, Irvine DJ, Alexander-Katz A (2013). "Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers." Nano Letters, 13:9 (2013). PMID: 23915118

Zheng Y, Stephan M, Gai SA, Abraham W, Shearer A, and Irvine DJ, "In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes," Journal of Controlled Release 172(2):426-35 (2013) . PMCID: PMC 4046900.

Su X, Yang N, Wittrup KD, and Irvine DJ, "Synergistic anti-tumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles," Biomacromolecules 14(4) 1093-1102 (2013). PMCID: PMC3646422.

Kwong B, and Irvine DJ, "Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity," Cancer Res. 73(5) 1547–58 (2013). PMCID: PMC3594475.

Ackerman M, Dugast A-S, McAndrew E, Tsoukas S, Licht A, Irvine DJ, and Alter G, "Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b" J. Virology 87(10):5468-76 (2013). PMCID: PMC3648186.

DeMuth PC, Min Y, Huang B, Kramer JA, Miller AD, Barouch DH, Hammond PT, and Irvine DJ, "Polymer multilayer tattooing for enhanced DNA vaccination," Nature Materials 12 367–376 (2013). PMCID: PMC3965298.

Wang Y and Irvine DJ, "Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes," Integrative Biology 5(3) 481-494 (2013). PMCID: PMC 3597436.

Mata-Fink J, Kriegsman B, Yu HX, Zhu H, Hanson MC, Irvine DJ, and Wittrup KD, "Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast," J. Mol. Biol. 425 444–456 (2013). PMCID: PMC 3785227.

 

2012

Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MSN, Lauffenburger DA, Irvine DJ, Love JC, "Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving," Anal. Chem. online (2012). PMCID: PMC3691955

DeMuth PC, Moon JJ, Suh H, Hammond PT, and Irvine DJ, "Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery," ACS Nano 6(9):8041-51 (2012). PMCID: PMC3475723.

DeMuth PC, Garcia-Beltran WF, Ai-Ling ML, Hammond PT, and Irvine DJ, "Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination," Adv. Funct. Mater. 23(2):161-172 (2012). PMCID: PMC3595545.

Stephan MT, Stephan S, Bak SP, Chen J, and Irvine DJ, "Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles," Biomaterials. 33(23) 5776-5787 (2012).

Moon JJ, Huang B, and Irvine DJ, "Engineering nano- and micro-particles to tune immunity," Advanced Materials. 24(28) 3724-3746 (2012).

Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, and Irvine DJ, "Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction," Proc. Natl. Acad. Sci., U.S.A. 109 1080-1085 (2012).

Moon JJ, Suh H, Polhemus ME, Ockenhouse CF, Yadava A, and Irvine DJ, "Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine," PLoS ONE 7, e31472 (2012).

Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, and Irvine DJ, "Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine," Journal of Controlled Release 157 3543-365 (2012). PMCID: PMC3811132.

Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, and Stephanopoulos G, "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia," Nature 481, 380–384 (2012).

 

2011

Jewell CM, Jung JM, Atukorale PU, Carney RP, Stellacci F, and Irvine DJ, "Oligonucleotide delivery by cell-penetrating "striped" nanoparticles," Angew. Chem. Intl. Ed. 50 12312-12315 (2011). PMID: 22028047

Jewell CM, Bustamante Lopez SC, and Irvine DJ, "In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles," Proc. Natl. Acad. Sci., U.S.A. 108(38) 15745-15750 (2011). PMCID: PMC3179077

Liu H, Kwong B, and Irvine DJ, "Membrane Anchored Immunostimulatory Oligonucleotides for in vivo Cell Modification and Localized Immunotherapy," Angew. Chemie Intl. Ed. 50 7052-7055 (2011). PMCID: PMC3166645

Kwong B, Liu H, and Irvine DJ, "Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy," Biomaterials 32(22) 5134-5147 (2011).

De Temmerman M-L, Rejman J, Demeester J, Irvine DJ, Gander B, and De Smedt SC, "Particulate vaccines: on the quest for optimal delivery and immune response," Drug Discovery Today 16 569-582 (2011).

Wang Y and Irvine DJ, "Engineering chemoattractant gradients using chemokine-releasing polysaccharide microspheres," Biomaterials 32(21) 4903-4913 (2011). PMCID: PMC3139910

Yoo J-W, Irvine DJ, Discher DE, and Mitragotri S, "Bio-inspired, bioengineering and biomimetic drug delivery carriers," Nature Reviews Drug Discovery 10(7) 521-535 (2011).

Stephan MT and Irvine DJ, "Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials," Nano Today 6 309-325 (2011). PMCID: PMC2935928

Su X, Fricke J, Kavanagh D, and Irvine DJ, "In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles," Molecular Pharmaceutics 8(3) 774-787 (2011).

Irvine, D. J., Drug delivery: One nanoparticle, one kill. Nature Materials 10, 342–343 (2011). PMCID: PMC3842662.

Irvine DJ and Jewell CM, "Vaccine and Immunotherapy Delivery", in Comprehensive Biomaterials, Ed. P. Ducheyne, Elsevier Press (2011).

Martinez-Martin N, Fernandez-Arenas E, Cemerski A, Delgado P, Turner M, Neuser J, Irvine DJ, Huang B, Bustelo XR, Shaw A, and Alarcon B, "T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis," Immunity 35(2) 208-222 (2011). PMCID: PMC4033310.

Palmer MJ, Mahajan VS, Chen J, Irvine, DJ, and Lauffenburger DA, "Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells," Immunology and Cell Biology 89(5) 581-594 (2011). **Highlighted as an Outstanding Observation by the journal.

Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM, "In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling," Biophysical Journal 100(8) 1893-1901 (2011). **Highlighted as a Featured Article by the journal.

Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Chiu W, and Irvine DJ, "Interbilayer-crosslinked multilamellar vesicles for potent humoral and cellular immune responses," Nature Materials 10(3) 243-251 (2011).

Ackerman ME, Moldt B., Wyatt, RT, Dugast A, McAndrew E, Tsoukas S, Jost S, Berger CT, Sciaranghella G, Liu Q, Irvine DJ, Burton DR, and Alter G, "A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples," Journal of Immunological Methods 366(1-2) 8-19 (2011).

 

2010

DeMuth P, Su X, Samuel RE, Hammond PT, and Irvine DJ, "Nano-Layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA," Advanced Materials, 22(43) 4851-4856 (2010). (cover article)

Stephan M, Moon JJ, Um SH, Bershteyn A, and Irvine DJ, "Therapeutic cell engineering with surface-conjugated synthetic nanoparticles," Nature Medicine, 16(9) 1035-1041 (2010).

Atala A, Irvine DJ, Moses M, and Shaunak S, "Wound healing versus regeneration: Role of the tissue environment in regenerative medicine," MRS Bulletin 35(8) 597-606 (2010).

Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, and Weiss A, "Regulation of thymocyte positive selection and motility by GIT2," Nature Immunology 11(6) 503-11 (2010).

Swiston AJ, Gilbert JB, Irvine DJ, Cohen RE, and Rubner MF, "Freely suspended cellular "backpacks" lead to cell self-assembly," Biomacromolecules 11 1826-1832 (2010).

 

2009

Hori Y, Stern PJ, Hynes RO, and Irvine DJ, "Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy," Biomaterials 30 6757-6767 (2009).

Su X, Kim BS, Kim SR, Hammond PT, and Irvine DJ, "Layer-by-Layer-Assembled multilayer films for transcutaneous drug and vaccine delivery," ACS Nano 3(11) 3719-3729 (2009).

Hu Y, Atukorale PU, Lu JJ, Moon JJ, Um SH, Cho EC, Wang Y, Chen J, and Irvine DJ, "Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles," Biomacromolecules,10 756-765 (2009). PMID: 19239276.

Maldonado RA, Soriano MA, Perdomo C, Sigrist K, Irvine DJ, Decker T, and Glimcher LH, "Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse," Journal of Experimental Medicine 206 877-892 (2009).

Hori Y, Winans AM, and Irvine DJ, "Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors," Acta Biomaterialia 5 969-982 (2009). PMCID: PMC3042245.

Miller AC, Bershteyn A, Tan W, Hammond PT, Cohen RE, and Irvine DJ, "Block copolymer micelles as nanocontainers for controlled release of proteins from biocompatible oil phases," Biomacromolecules 10 732-741 (2009).

 

2008

Hori Y, Winans AM, Huang CC, Horrigan EM, and Irvine DJ, "Injectable dendritic cell-carrying alginate gels for immunization and immunotherapy," Biomaterials 29 3671-3682 (2008).

Swiston AJ, Cheng C, Um SH, Irvine DJ, Cohen RE, and Rubner MF, "Surface functionalization of living cells with multilayer patches," Nano Letters 8 4446-4453 (2008).

Verma A, Uzun O, Hu Y, Watson N, Chen S, Irvine DJ, and Stellacci F, "Cell penetrating nanoparticles: the role of ligand shell structure," Nature Materials, 7 588-595 (2008). PMCID: PMC2684029

Bershteyn A, Chaparro J, Yau R, Kim M, Reinherz E, Ferreira-Moita L, and Irvine DJ, "Polymer-Supported lipid shells, onions, and flowers," Soft Matter 4 1787-1791 (2008). PMCID: PMC2743563

Miller AC, Bennett RD, Hammond, PT, Irvine DJ, and Cohen RE, "Functional nanocavity arrays via amphiphilic block copolymer thin films," Macromolecules 41(5) 1739-1744 (2008).

Irvine DJ, Stachowiak AN, and Y Hori, "Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity," Seminars in Immunology 20 137-146 (2008).

Stachowiak AN and Irvine DJ, "Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration," Journal of Biomedical Materials Research 85A 815-828 (2008).

 

2007 and earlier

Hu Y, Litwin T, Nagaraja AR, Kwong B, Katz J, Watson N, and Irvine DJ, "Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles," Nano Letters, 7(10); 3056-3064 (2007). [Abstract]

Irvine DJ, Doh J, and Huang B, "Patterned surfaces as tools to study ligand recognition and synapse formation by T cells," Current Opinion in Immunology 19 463-469, (2007).

Irvine DJ, Doh J, "Synthetic surfaces as artificial antigen presenting cells in the study of T cell receptor triggering and immunological synapse formation," Seminars in Immunology 19 245-254 (2007).

Stachowiak AN, Wang Y, Huang Y-C, and Irvine DJ, "Homeostatic lymphoid chemokines synergize with adhesion ligands to trigger T and B lymphocyte chemokinesis," The Journal of Immunology, 177(4) 2340-2348 (2006). [full text]

Doh J, and Irvine DJ, "Immunological Synapse Arrays: Patterned Protein Surfaces that Template Immunological Synapse Structure Formation in T Cells," J. Doh and D.J. Irvine, Proceedings of the National Academy of Sciences, U.S.A., 103(15) 5700-5705 (2006). [full text]

Kim H, Cohen RE, Hammond PT, and Irvine DJ, "Live Lymphocyte Arrays for Biosensing," Advanced Functional Materials, 16 1313-1323 (2006). [Abstract]

"Composition-tunable properties of amphiphilic comb copolymers containing protected methacrylic acid groups for multicomponent protein patterning," J.S. Katz, J. Doh, and D.J. Irvine, Langmuir 22 (1) 353-359 (2006). [Abstract] [PDF]

Bennett, R.D., Hart, A.J., Miller, A.C., Hammond, P.T., Irvine, D.J., and R.E. Cohen, "Creating patterned carbon nanotube catalysts through the microcontact printing of block copolymer micellar thin films," Langmuir 22(20) 8273-8276 (2006). [Abstract]

"Strategies for controlling the planar arrangement of block copolymer micelles and inorganic nanoclusters," R.D. Bennette, A.C. Miller, N.T. Kohen, P.T. Hammond, D.J. Irvine, and R.E. Cohen, Macromolecules 38 (26) 10728-10735 (2005). [Abstract] [PDF]

"Synthesis of protein-loaded hydrogel particles in an aqueous two-phase system for coincident antigen and CpG oligonucleotide delivery to antigen-presenting cells," S. Jain, W.T. Yap, and D.J. Irvine, Biomacromolecules 6 (5) 2590-2600 (2005). [Abstract] [PDF]

"beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization," J.R. Greenland, H.N. Liu, D. Berry, D.G. Anderson, W.K. Kim, D.J. Irvine, R. Langer, and N.L. Letvin, Molecular Therapy 12 (1) 164-170 (2005). [Abstract] [PDF]

"Directed cell migration via chemoattractants released from degradable microspheres," X. Zhao, S. Jain, B. Larman, S. Gonzalez, and D.J. Irvine, Biomaterials 26 (24) 5048-5063 (2005). [Abstract] [PDF]

"Bioactive hydrogels with an ordered cellular structure combine interconnected macroporosity and robust mechanical properties," A.N. Stachowiak, A. Bershteyn, and D.J. Irvine, Adv. Mater. 17 (4) 399 (2005).

"A role for the immunological synapse in lineage commitment of CD4 lymphocytes," R.A. Maldonado, D.J. Irvine, R. Schreiber, and L.H. Glimcher, Nature 431 527-532 (2004). [Abstract] [PDF]

"Photogenerated polyelectrolyte bilayers from an aqueous-processible photoresist for multiple protein patterning," J. Doh, and D.J. Irvine, J. Am. Chem. Soc., 126 (30) 9170-9171 (2004). [Abstract] [PDF]

"CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse," Q.J. Li, A.R. Dinner, S.Y. Qi, D.J. Irvine, J.B. Huppa, M.M. Davis, and A.K. Chakraborty, Nature Immunology , 5(8) 791-799 (2004). [Abstract] [PDF]

"T cell killing does not require the formation of a stable mature immunological synapse," M.A. Purbhoo, D.J. Irvine, J.B. Huppa , and M.M. Davis, Nature Immunology , 5 524-530 (2004). [Abstract] [PDF]

"Large Area Two-Dimensional B Cell Arrays for Sensing and Cell-Sorting Applications," H. Kim, J. Doh, D.J. Irvine, R.E. Cohen, and P.T. Hammond, Biomacromolecules , 5 822-827 (2004). [Abstract] [PDF]

"Function-specific variations in the immunological synapses formed by cytotoxic T cells," D.J. Irvine, Proc. Natl. Acad. Sci. USA 100 , 13739-13740 (2003). [Abstract] [PDF]

"Engineering biomaterials for control of immune cell functions," D.J. Irvine, A. Stachowiak, and S. Jain, Materials Science Forum , 426-4 3213-3218 (2003).

"Dynamics of cell surface molecules during T cell recognition," M.M.Davis, M. Krogsgaard, J.B.Huppa, C. Suman, M.A. Purbhoo, D.J. Irvine, L.C. Wu, and L. Ehrlich, Annual Review of Biochemistry , 72 712-742 (2003).  [Abstract] [PDF]

"Direct observation of ligand recognition by T cells," D.J. Irvine, M.A. Purbhoo, M. Krogsgaard, and M.M. Davis, Nature, 419(6909) 845-849 (2002). [Abstract] [PDF]

"Rapid signaling-induced receptor reorientation in the formation of the immunological synapse," W. Moss, D.J. Irvine, M. Krummel, and M.M. Davis, Proc. Natl. Acad. Sci. USA 99, 15024-15029 (2002). [Abstract] [PDF]

"Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus," Lily Y. Koo, Darrell J. Irvine, Anne M. Mayes, Douglas A. Lauffenburger, and Linda G. Griffith, J. Cell Sci. 115 1423-1433 (2002). [Abstract] [PDF]

"Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands," D.J. Irvine, K.-A. Hue, A.M. Mayes, and L.G. Griffith, Biophys. J., 82(1) 120-132 (2002). [Abstract] [PDF]

"Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 2. Surface Segregation of Comb Polymers in Polylactide," D.J. Irvine, A.-V. Ruzette, A.M. Mayes, and L.G. Griffith, Biomacromolecules, 2(2) 545-556 (2001). [Abstract] [PDF]

"Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 1. Synthesis and Characterization of Comb Thin Films," D.J. Irvine, A.M. Mayes, and L.G. Griffith, Biomacromolecules, 2(1) 85-94 (2001). [Abstract] [PDF]

"Polymer Latexes for Cell-Resistant or Cell-Interactive Surfaces," P. Banerjee, D.J. Irvine, A.M. Mayes, and L.G. Griffith, J. Biomed. Mater. Res., 50(3) 331-339 (2000). [Abstract] [PDF]

"Tailored Polymer Surfaces for Controlled Cell Interactions," A.M. Mayes, D.J. Irvine, and L.G. Griffith, Mater. Res. Soc. Symp. Proc., 530, 73-84 (1998).

"Comparison of Tethered Star and Linear Poly(Ethylene Oxide) for Control of Biomaterials Surface Properties," D.J. Irvine, A.M. Mayes, S.K. Satija, J.G. Barker, S.J. Sofia-Allgor, and L.G. Griffith, Journal of Biomedical Materials Research, 40(3) 498-509 (1998). [Abstract] [PDF]

"Design of Biocompatible Surfaces," A.M. Mayes, D.G. Walton, D.J. Irvine, and L. Griffith, Amer. Chem. Soc. Proc. Div. Mat. Sci. Eng., 75, 78-79 (1996).

"Self-Consistent Field Analysis of Grafted Star Polymers," D.J. Irvine, A.M. Mayes, and L. Griffith-Cima, Macromolecules, 29(18) 6037-6043 (1996). [Abstract] [PDF]

"Computer Simulations of Self-Assembling Comb copolymers," D.J. Irvine, D. Gersappe, and A.C.Balazs, Langmuir, 11(10) 3848-3855 (1995). [Abstract] [PDF]

"The Use of Graft Copolymers to Bind Immiscible Blends," D. Gersappe, D. Irvine, A.C. Balazs, Y. Liu, J. Sokolov, M. Rafailovich, S. Schwarz, and D.G. Peiffer, Science, 265(5175) 1072-1074 (1994). [Abstract] [PDF]

"Contrasting the Compatibilizing Activities of Comb and Linear Copolymers," D. Gersappe, P.K. Harm, D. Irvine, and A.C. Balazs, Macromolecules, 27 (3) 720-724 (1994). [Abstract] [PDF]