Vaccine design using smart materials and nanotechnology

A key goal of our laboratory is to engineer enhanced immunity through the design of materials that control the immune response elicited by vaccines. We have focused in two main areas: (i) nanoparticle-based strategies to enhance subunit vaccines and (ii) microneedle technologies for non-invasive vaccine/drug delivery through the skin. In collaborative efforts with faculty from the Ragon Institute of MGH, MIT, and Harvard, we have applied these technologies toward the design of a vaccine for HIV, while with colleagues from the Koch Institute, we focus on using these approaches to enhance therapeutic cancer vaccines.

Vaccine design