Read BJ, Won L, Kraft JC, Sappington I, Aung A, Wu S, Bals J, Chen C, Lee KK, Lingwood D, King NP, and Irvine DJ, “Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens,” Cell Rep (2022). PMID: 35021101. doi:10.1016/j.celrep.2021.110217.

Agarwal Y, Milling LE, Chang JYH, Santollani L, Sheen A, Lutz E, Tabet A, Stinson J, Ni K, Rodrigues K, Moyer TJ, Melo MB, Irvine DJ, and Wittrup KD. “Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity,” Nat Biomed Eng (2022). PMID: TBD. doi:10.1038/s41551-021-00831-9.

Milling LE, Garafola D, Agarwal Y, Wu S, Thomas A, Donahue N, Adams J, Thai N, Suh H, and Irvine DJ. “Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation,” Cancer Immunol Res (2022). PMCID: PMC8732307. doi:10.1158/2326-6066.CIR-21-0247.



Rodrigues KA, Rodriguez-Aponte SA, Dalvie NC, Lee JH, Abraham W, Carnathan DG, Jimenez LE, Ngo JT, Chang JYH, Zhang Z, Yu J, Chang A, Nakao C, Goodwin B, Naranjo CA, Zhang L, Silva M, Barouch DH, Silvestri G, Crotty S, Love JC, and Irvine DJ. “Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2,” Sci Adv (2021). PMCID: PMC8654298. doi:10.1126/sciadv.abj6538.

Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, and Irvine DJ. “A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity,” Sci Immunol (2021). PMID: 34860581. doi:10.1126/sciimmunol.abf1152.

Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West AP Jr, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ. “Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env,” Sci Trans Med (2021). PMID: 34818054. doi:10.1126/scitranslmed.abk1533.

Wang C, Cui A, Bukenya M, Aung A, Pradhan D, Whittaker CA, Agarwal Y, Thomas A, Liang S, Amlashi P, Suh H, Spranger S, Hacohen N, and Irvine DJ. “Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade,” Cell Rep (2021). PMID: 34818534. doi:10.1016/j.celrep.2021.110021.

Sriram G, Milling LE, Chen JK, Kong YW, Joughin BA, Abraham W, Swartwout S, Handly ED, Irvine DJ, and Yaffe MB. “The injury response to DNA damage in live tumor cells promotes antitumor immunity,” Sci Signal (2021). PMID: 34665642. doi:10.1126/scisignal.abc4764.

Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, and Jacks T. “Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer,” Nat Cancer (2021). PMCID: PMC8562866. doi:10.1038/s43018-021-00247-z.

Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru OS, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Brunette N, Wang JY, Walkey C, Fiala B, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, and Love JC. “Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice,” Proc Natl Acad Sci U S A. (2021). PMCID: PMC8463846. doi:10.1073/pnas.2106845118.

Knappe GA, Wamhoff E, Read BJ, Irvine DJ, and Bathe M. “In Situ Covalent Functionalization of DNA Origami Virus-like Particles,” ACS Nano. (2021). PMCID: PMC8628367. doi:10.1021/acsnano.1c03158.

Loftis AR, Zhang G, Backlund C, Quartararo AJ, Pishesha N, Hanna CC, Schissel CK, Garafola D, Loas A, Collier RJ, Ploegh H, Irvine DJ, and Pentelute BL. “An in vivo selection-derived d-peptide for engineering erythrocyte-binding antigens that promote immune tolerance,” Proc Natl Acad Sci U S A. (2021). PMCID: PMC8403921. doi:10.1073/pnas.2101596118.

Martin JT, Hartwell BL, Kumarapperuma SC, Melo MB, Carnathan DG, Cossette BJ, Adams J, Gong S, Zhang W, Tokatlian T, Menis S, Schiffner T, Franklin CG, Goins B, Fox PT, Silvestri G, Schief WR, Ruprecht RM, and Irvine DJ. “Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates,” Biomaterials. (2021). PMID: 34091299. doi:10.1016/j.biomaterials.2021.120868.

Bhagchandani S, Johnson JA, and Irvine DJ. “Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants,” Adv Drug Deliv Rev. (2021). PMID: 34058283. doi:10.1016/j.addr.2021.05.013.

Chang JYH, and Irvine DJ. “Engineering autoreactive T and B cell responses toward active immunotherapy for inflammatory diseases,” Proc Natl Acad Sci USA. (2021). PMCID: PMC8157984. doi:10.1073/pnas.2104743118.

Kang BH, Momin N, Moynihan KD, Silva M, Li Y, Irvine DJ, Wittrup KD. “Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice,” PloS one. (2021). PMCID: PMC8049297. doi:10.1371/journal.pone.0248903.

Steinbach S, Jalili-Firoozinezhad S, Srinivasan S, Melo MB, Middleton S, Konold T, Coad M, Hammond PT, Irvine DJ, Vordermeier M, and Kapur V. “Temporal dynamics of intradermal cytokine response to tuberculin in Mycobacterium bovis BCG-vaccinated cattle using sampling microneedles,” Sci Rep. (2021). PMID: TBD. doi:10.1038/s41598-021-86398-6.

Rakhra K, Abraham W, Wang C, Moynihan KD, Li N, Donahue N, Baldeon AD, and Irvine DJ. “Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells,” Sci Immunol.  (2021). PMCID: PMC8279396 . doi:10.1126/sciimmunol.abd8003.

McCafferty S, De Temmerman J, Kitada T, Becraft JR, Weiss R, Irvine DJ, Devreese M, De Baere S, Combes F, and Sanders NN. “In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation,” Mol Ther. (2021). PMCID: PMC7934578 . doi:10.1016/j.ymthe.2020.11.010.

Huang S, Lin CW, Qi J, Iyer AM, He Y, Li Y, Bardhan NM, Irvine DJ, Hammond PT, and Belcher AM. “Surface Plasmon-Enhanced Short-Wave Infrared Fluorescence for Detecting Sub-Millimeter-Sized Tumors,” Adv Mater. (2021). PMID: 33448062. doi:10.1002/adma.202006057.

Lu Z, Truex NL, Melo MB, Cheng Y, Li N, Irvine DJ, and Pentelute BL. “IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells,” ACS Cent. Sci. (2021). PMID: TBD. doi:10.1021/acscentsci.0c01670.

Kumari S, Irvine DJ. “Morphological Definition of Actin Architecture at the T Cell Immunological Synapse,” J Indian Inst Sci. (2021). PMID: TBD. doi:10.1007/s41745-020-00216-y.

Pires IS, Hammond PT, and Irvine DJ. “Engineering Strategies for Immunomodulatory Cytokine Therapies: Challenges and Clinical Progress,” Adv. Therap. (2021). PMID: TBD. doi:10.1002/adtp.202100035.



McCafferty S, De Temmerman J, Kitada T, Becraft JR, Weiss R, Irvine DJ, Devreese M, De Baere S, Combes F, Sanders NN. “In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation,” Mol Ther  (2020). PMID: 33186690. doi:10.1016/j.ymthe.2020.11.010.

Eskandari SK, Sulkaj I, Melo MB, Li N, Allos H, Alhaddad JB, Kollar B, Borges TJ, Eskandari AS, Zinter MA, Cai S, Assaker JP, Choi JY, Al Dulaijan BS, Mansouri A, Haik Y, Tannous BA, van Son WJ, Leuvenink HGD, Pomahac B, Riella LV, Tang L, Seelen MAJ, Irvine DJ, Azzi JR. “Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter,” Sci Trans Med  (2020). PMID: 33177180. doi:10.1126/scitranslmed.aaw4744.

Li Y, Su Z, Zhao W, Zhang X, Momin N, Zhang C, Wittrup KD, Dong Y, Irvine DJ, Weiss R. “Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity,” Nat Cancer  (2020). PMCID: TBD. doi:10.1038/s43018-020-0095-6.

Kato Y, Abbott RK, Freeman BL, Haupt S, Groschel B, Silva M, Menis S, Irvine DJ, Schief WR, Crotty S. “Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo,” Immunity  (2020). PMCID: PMC7451196. doi:10.1016/j.immuni.2020.08.001.

Tahir MA, Guven ZP, Arriaga LR, Tinao B, Yang YS, Bekdemir A, Martin JT, Bhanji AN, Irvine DJ, Stellacci F, Alexander-Katz A. “Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles,” PNAS  (2020). PMCID: PMC7414053. doi:10.1073/pnas.1902597117.

Veneziano R, Moyer T, Stone M, Wamhoff E, Read B, Mukherjee S, Shepherd T, Das J, Schief W, Irvine DJ, Bathe, M. “Role of nanoscale antigen organization on B-cell activation probed using DNA origami,” Nat Nanotechnol  (2020). PMCID: PMC7415668. doi:10.1038/s41565-020-0719-0.

Irvine DJ, Aung A, Silva M. “Controlling timing and location in vaccines,” Adv Drug Deliv Rev  (2020). PMCID: PMC7318960. doi:10.1016/j.addr.2020.06.019.

Vohidov F, Milling L, Chen Q, Zhang W, Bhagchandani S, Nguyen HVT, Irvine DJ, Johnson JA. “ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy,” Chem Sci  (2020). PMID: TBD. doi:10.1039/D0SC02611E.

Gilfillan C, Wang C, Mohsen M, Rufer N, Hebeisen M, Allard M, Verdeil G, Irvine DJ, Bachmann M, Speiser D. “Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density,” European Journal of Immunology  50(4), 505-514 (2020). PMCID: PMC7187562. doi:10.1002/eji.201948355.

Irvine DJ, Read B. “Shaping humoral immunity to vaccines through antigen-displaying nanoparticles,” Current Opinion in Immunology (2020). PMID: 32200132. doi:10.1016/j.coi.2020.01.007.

Mehta N, Pradhan R, Soleimany A, Moynihan K, Rothschilds A, Momin N, Rakhr, K, Mata-Fink J, Bhatia S, Wittrup K, Irvine DJ. “Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines,” Nat Biomed Eng (2020). PMID: TBD. doi:10.1038/s41551-020-0563-4.

Moyer TJ, Kato Y, Abraham W, Chang JYH, Kulp DW, Watson N, Turner HL, Menis S, Abbott RK, Bhiman JN, Melo MB, Simon HA, Herrera-De la Mata S, Liang S, Seumois G, Agarwal Y, Li N, Burton DR, Ward AB, Schief WR, Crotty S, Irvine DJ. “Engineered immunogen binding to alum adjuvant enhances humoral immunity,” Nat Med 1-11 (2020). PMID: 32066977. doi:10.1038/s41591-020-0753-3.

Sriram G, Milling L, Chen J, Abraham W, Irvine DJ, Yaffe MB. “Intratumoral administration of DNA-damaging chemotherapy-treated tumor cells to enhance therapeutic benefit of systemic immune checkpoint blockade in mouse cancer models.,” Journal of Clinical Oncology 38, no. 5_suppl (2020). doi:10.1200/JCO.2020.38.5_suppl.77.

Irvine DJ, Dane, EL. “Enhancing cancer immunotherapy with nanomedicine,” Nat Rev Immunol (2020). doi:10.1038/s41577-019-0269-6.

Kumari S, Mak M, Poh YC, Tohme M, Watson N, Melo M, Janssen E, Dustin M, Geha R, Irvine DJ, Pillai S. “Cytoskeletal tension actively sustains the migratory T-cell synaptic contact,” EMBO J e102783 (2020). PMID: 31894880. doi:10.15252/embj.2019102783.
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Mahajan VS, Demissie E, Alsufyani F, Kumari S, Yuen GJ, Viswanadham V, Huang A, Tran JQ, Moon JJ, Irvine DJ, Pillai S. “DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering,” J Immunol 204(1):49-57 (2020). PMCID: PMC6920543. doi:10.4049/jimmunol.1900440.



Melo M, Porter E, Zhang Y, Silva M, Li N, Dobosh B, Liguori A, Skog P, Landais E, Menis S, Sok D, Nemazee D, Schief WR, Weiss R, Irvine DJ. “Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles,” Mol Ther 27(12):2080-2090 (2019). PMCID: PMC6904793. doi:10.1016/j.ymthe.2019.08.007.

Gilfillan CB, Wang C, Mohsen MO, Rufer N, Hebeisen M, Allard M, Verdeil G, Irvine DJ, Bachmann MF, Speiser DE. “Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density,” Eur J Immunol Epub ahead of print (2019). PMID: 31785153. doi:10.1002/eji.201948355.

Loukogeorgakis SP, Fachin CG, Dias AIBS, Li H, Tang L, Kim AG, Vrecenak JD, Stratigis JD, Ahn NJ, Nissim I, Nissim I, Moron AF, Martins JL, Peranteau WH, De Coppi P, Irvine DJ, Flake AW. “Donor cell engineering with GSK3 inhibitor-loaded nanoparticles enhances engraftment after in utero transplantation,” Blood 134(22):1983-1995 (2019). PMID: 31570489. doi:10.1182/blood.2019001037.

Havenar-Daughton C, Carnathan DG, Boopathy AV, Upadhyay AA, Murrell B, Reiss SM, Enemuo CA, Gebru EH, Choe Y, Dhadvai P, Viviano F, Kaushik K, Bhiman JN, Briney B, Burton DR, Bosinger SE, Schief WR, Irvine DJ, Silvestri G, Crotty S. “Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization,” Cell Rep 29(7):1756-1766.e8 (2019). PMCID: PMC6905039. doi:10.1016/j.celrep.2019.10.008

Kumari S, Colin-York H, Irvine DJ, Fritzsche M.“Not All T Cell Synapses Are Built the Same Way,” Trends Immunol 40(11):977-980 (2019). PMID: 31645298. doi:10.1016/

Fotoran WL, Müntefering T, Kleiber N, Miranda BNM, Liebau E, Irvine DJ, Wunderlich G.“A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy,” Nanomedicine 22:102099 (2019). PMID: 31648039. doi:10.1016/j.nano.2019.102099

Al Sulaiman D, Chang JYH, Bennett NR, Topouzi H, Higgins CA, Irvine DJ, Ladame S. “Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid,” ACS Nano 11(498). pii: eaaw2614 (2019). PMCID: PMC6746174. doi:10.1021/acsnano.9b04783

Boopathy AV, Mandal A, Kulp DW, Menis S, Bennett NR, Watkins HC, Wang W, Martin JT, Thai NT, He Y, Scief WR, Hammond PT, and Irvine DJ. “Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination,” PNAS 116(33):1-6 (2019). PMCID: PMC6697788. doi:10.1073/pnas.1902179116

Ma L, Dichwalkar T, Chang JYH, Cossette B, Garafola D, Zhang AQ, Fichter M, Wang C, Liang S, Silva M, Kumari S, Mehta NK, Abraham W, Thai N, Li N, Wittrup KD, and Irvine DJ. “Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor,” Science 365(6449):162-168 (2019). PMCID: PMC6800571. doi:10.1126/science.aav8692
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Momin N, Mehta NK, Bennett NR, Ma L, Palmeri JR, Chinn MM, Lutz EA, Kang B, Irvine DJ, Spranger S, Wittrup KD. “Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy,” Sci Transl Med 11(498). pii: eaaw2614 (2019). PMID: 31243150. doi:10.1126/scitranslmed.aaw2614

Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West AP Jr, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC. “Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques,” Nature 570(7762):468-473 (2019). PMCID: PMC6657810. doi:10.1038/s41586-019-1250-z

Cirelli KM, Carnathan DG, Nogal B, Martin JT, Rodriguez OL, Upadhyay AA, Enemuo CA, Gebru EH, Choe Y, Viviano F, Nakao C, pauthner MG, Reiss S, Cottrell CA, Smith ML, Bastidas R, Gibson W, Wolabaugh AN, Melo MB, Cossette B, Kumar V, Patel NB, Tokatlian T, Menis S, Kulp DW, Burton DR, Murrell B, Schief WR, Bosinger SE, Ward AB, Watson CT, Silvestri G, Irvine DJ, Crotty S. "Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance," Cell (2019). PMCID: PMC6619430. doi:10.1016/j.cell.2019.04.012.

Li Y, Teague B, Zhang Y, Su Z, Porter E, Dobosh B, Wagner T, Irvine DJ, Weiss R. "In vitro evolution of enhanced RNA replicons for immunotherapy," Scientific Reports 9(1):6932 (2019). PMCID: PMC6502795. doi:10.1038/s41598-019-43422-0.
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Rothschilds, A, Tzeng, A, Mehta, NK, Moynihan, KD, Irvine, DJ & Wittrup, KD. "Order of administration of combination cytokine therapies can decouple toxicity from efficacy in syngeneic mouse tumor models," OncoImmunology 8, e1558678, (2019). PMCID: PMC31069130 doi:10.1080/2162402X.2018.1558678.

Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Jon M. Steichen, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, and Irvine DJ, “Innate immune recognition of glycans targets nanoparticle HIV immunogens to germinal centers,” Science 363(6427):649-654 (2019). PMCID: PMC30573546 doi:10.1126/science.aat9120.
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Pauthner MG, Nkolola JP, Havenar-Daughton C, Murrell B, Reiss SM, Bastidas R, Prévost J, Nedellec R, von Bredow B, Cottrell CA, Kulp DW, Tokatlian T, Nogal B, Bianchi M, Li H, Butera ST, Evans DT, Hangartner L, Finzi A, Wilson IA, Wyatt RT, Irvine DJ, Schief WR, Ward AB, Sanders RW, Crotty S, Shaw GM, Barouch DH, and Burton DR. “Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers,” Immunity 50(1):241-252 (2019). PMCID: PMC6335502 doi:10.1016/j.immuni.2018.11.011.

Kumari, S, Mak, M, Poh, Y, Tohme, M, Watson, N, Melo, M, Janssen, E, Dustin, M, Geha, R & Irvine, DJ. "Cytoskeletal tension actively sustains the migratory T cell synaptic contact," bioRxiv, 437236, (2019). doi:10.1101/437236.

Demissie, E, Mahajan, VS, Alsufyani, F, Kumari, S, Yuen, GJ, Viswanadham, V, Tran, JQ, Moon, JJ, Irvine, DJ & Pillai, S. "DOCK2 sets the threshold for entry into the virtual memory CD8+ T cell compartment by negatively regulating tonic TCR triggering," bioRxiv, 582486, (2019). PMCID: PMC31740487 doi:10.4049/jimmunol.1900440.

Xie, YQ, Arik, H, Wei, L, Zheng, Y, Suh, H, Irvine, DJ and Tang, L. "Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells," Biomater Sci 7, 1345-1357, (2019). PMCID: PMC30698174 doi:10.1039/c8bm01556b.

Mottas I, Bekdemir A, Cereghetti A, Spagnuolo L, Yang YSS, Müller M, Irvine DJ, Stellacci F, Bourquin C. “Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation,” Biomaterials 190-191 111-120 (2019). PMCID: PMC30415018 doi:10.1016/j.biomaterials.2018.10.031.

Yang YS, Moynihan KD, Bekdemir A, Dischwalker TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, and Irvine DJ. “Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles,” Biomaterials Science 7:113-124 (2019). PMCID: PMC6310171 doi:10.1039/c8bm01208c.



Mandal A, Boopathy AV, Lam LKW, Moynihan KD, Welch ME, Bennett NR, Turvey ME, Thai N, Van JH, Love JC, Hammond PT, and Irvine DJ, “Cell- and Fluid-Sampling Microneedle Patches for Monitoring Tissue- Resident Immunity,” Science Translational Medicine 10(467) eaar2227 1-14 (2018). PMCID: Pubmed Journal in process. doi:10.1126/scitranslmed.aar2227
Featured on the cover: Tapping into tissue immunity

Tokatlian T, Kulp DW, Mutafyan AA, Jones CA, Menis S, Georgeson E, Kubitz M, Zhang MH, Melo MB, Silva M, Yun DS, Schief WR, and Irvine DJ, “Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes,” Scientific Reports 8(16527):1-13 (2018). PMCID: PMC6224390 doi:10.1038/s41598-018-34853-2

He Y, Hong C, Li J, Howard MT, Li Y, Turvey ME, Uppu DSSM, Martin JR, Zhang K, Irvine DJ, and Hammond PT, “Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination,” ACS Nano 12(10):10272-10280 (2018). PMCID: Pubmed Journal in process. doi:10.1021/acsnano.8b05373

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Panloza-Macmaster P, Abbink P, Blass E, Trgoning JS, Irvine DJ, and Barouch DH, “Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy,” The Journal of Immunology 201(9):2744-2752 (2018). PMCID: PMC6196294 doi:10.4049/jimmunol.1800885

Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Le Gall S, Pentelute BL, and Irvine DJ, “Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability,” Cancer Immunology Research 6(9):1025-1038 (2018). PMCID: PMC6247902 doi:10.1158/2326-6066.CIR-17-0607

Tang L, Zheng Y, Melo M, Mabardi L, Castaño AP, Xie Y-Q, Li N, Kudchodkar SB, Wong HC, Jeng EK, Maus MV, and Irvine DJ, “Enhancing T-cell therapy through TCR signaling-responsive nanoparticle drug delivery,” Nature Biotechnology 36(8):707-716 (2018). PMCID: PMC6078803 doi:10.1038/nbt.4181
Featured on the cover: An illustration of a tumor surrounded by T cells bearing cytokine 'backpacks'. The cytokine-delivery system developed by Tang et al. releases cytokines specifically at the tumor after T cells recognize a tumor antigen

Atukorale PU, Guven ZP, Bekdemir A, Carney RP, Van Lehn RC, Yun DS, Jacob Silva PH, Demurtas D, Yang YS, Alexander-Katz A, Stellacci FR, and Irvine DJ, “Structure-Property Relationships of Amphiphilic Nanoparticles That Penetrate or Fuse Lipid Membranes,” Bioconjugate Chemistry 29(4):1131-1140 (2018). PMCID: PMC6311100 doi:10.1021/acs.bioconjchem.7b00777

Zhang Y, Li N, Suh H, and Irvine DJ, “Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity,” Nature Communications 9(1):6 (2018). PMCID: PMC5750237 doi:10.1038/s41467-017-02251-3



Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine, Michael S. Goldberg (2017). T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat. Commun. 8(1): 1–11. PMCID: PMC5700944 doi:10.1038/s41467-017-01830-8

Fan, Y., Kuai, R., Xu, Y., Ochyl, L. J., Irvine, D. J., Moon, J. J. (2017). Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy. Nano Letters. 17(12): 7387–7393. PMCID: PMC5821496 doi:10.1021/acs.nanolett.7b03218

Yanpu He, Jiahe Li, Michelle E Turvey, MayLin T Funkenbusch, Celestine Hong, Divakara SSM Uppu, Hongkun He, Darrell J Irvine, Paula T Hammond (2017). Synthetic Lift-off Polymer beneath Layer-by-Layer Films for Surface-Mediated Drug Delivery. ACS Macro Letters. 6(11): 1320–1324. doi:10.1021/acsmacrolett.7b00584

Appelbe, O. K., Moynihan, K. D., Flor, A., Rymut, N., Irvine, D. J., & Kron, S. J. (2017). Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide. J. Control. Release . 266: 248–255. PMCID: PMC5723529 doi:10.1016/j.jconrel.2017.09.043

Erin Janssen, Sudha Kumari, Mira Tohme, Sumana Ullas, Victor Barrera, Jeroen M.J. Tas, Marcela Castillo-Rama, Roderick T. Bronson, Shariq M. Usmani, Darrell J. Irvine, Thorsten R. Mempel, and Raif S. Geha. (2017). DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2(19): 1–18. PMCID: PMC5841868 doi:10.1172/jci.insight.94298

Moynihan, K. D. and Irvine, D. J. (2017). Roles for Innate Immunity in Combination Immunotherapies. Cancer Research, 77(19), 5215–5221. PMCID: PMC5647817 doi:10.1158/0008-5472.CAN-17-1340

Fotoran, W. L., Santangelo, R., de Miranda, B. N. M., Irvine, D. J., & Wunderlich, G. (2017). DNA-Loaded Cationic Liposomes Efficiently Function as a Vaccine against Malarial Proteins. Molecular Therapy: Methods & Clinical Development. 7: 1–10. PMCID: PMC5581859 doi:10.1016/j.omtm.2017.08.004

Matthias Pauthner, Colin Havenar-Daughton, Devin Sok, Joseph P. Nkolola, Raiza Bastidas, Archana V. Boopathy, Diane G. Carnathan, Abishek Chandrashekar, Kimberly M. Cirelli, Christopher A. Cottrell, Alexey M. Eroshkin, Javier Guenaga, Kirti Kaushik, Daniel W. Kulp, Jinyan Liu, Laura E. McCoy, Aaron L. Oom, Gabriel Ozorowski, Kai W. Post, Shailendra K. Sharma, Jon M. Steichen, Steven W. de Taeye, Talar Tokatlian, Alba Torrents de la Peña, Salvatore T. Butera, Celia C. LaBranche, David C. Montefiori, Guido Silvestri, Ian A. Wilson, Darrell J. Irvine, Rogier W. Sanders, William R. Schief, Andrew B. Ward, Richard T. Wyatt, Dan H. Barouch, Shane Crotty, Dennis R. Burton (2017). Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches. Immunity 46: 1073–1088. PMCID: PMC5483234 doi:10.1016/j.immuni.2017.05.007

Lauren Milling, Yuan Zhang, Darrell J. Irvine (2017). Delivering safer immunotherapies for cancer. Adv. Drug Deliv. Rev. 114(C): 79-101. PMCID: PMC5647831 doi:10.1016/j.addr.2017.05.011

Wilfred Ngwa, Francis Boateng, Rajiv Kumar, Darrell J. Irvine, Silvia Formenti, Twalib Ngoma, Carsten Herskind, Marlon R. Veldwijk, Georg Lars Hildenbrand (2017). Smart Radiation Therapy Biomaterials. Int. J. Radiat. Oncol. 97(3): 624-637. PMCID: PMC5302132 doi:10.1016/j.ijrobp.2016.10.034

Yiran Zheng, Li Tang, Llian Mabardi, Sudha Kumari, and Darrell J. Irvine (2017). Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors. ACS Nano. 11(3): 3089–3100. PMCID: PMC5750237 doi:10.1021/acsnano.7b00078

Jiahe Li, Wade Wang, Yanpu He, Yingzhong Li, Emily Z. Yan, Ketian Zhang, Darrell J. Irvine, and Paula T. Hammond (2017). Structurally Programmed Assembly of Translation Initiation Nanoplex for Superior mRNA Delivery. ACS Nano. 11(3): 2531–2544. PMCID: PMC5629916 doi:10.1021/acsnano.6b08447

R. Brad Jones, Stephanie Mueller, Sudha Kumari, Vlad Vrbanac, Shy Genel, Andrew M. Tager, Todd M. Allen, Bruce D. Walker, Darrell J. Irvine (2017). Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells. Biomaterials. 117: 44-53. PMCID: PMC5204257 doi:10.1016/j.biomaterials.2016.11.048

Yu-Sang Sabrina Yang, Prabhani U. Atukorale, Kelly D. Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci & Darrell J. Irvine (2017). High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry. Nat. Commun. 8: 14069 PMCID: PMC5247578 doi:10.1038/ncomms14069



Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader (2016). Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat. Commun. 7: 13894 PMCID: PMC5192216 doi:10.1038/ncomms13894

Alice Tzeng, Monique J. Kauke, Eric F. Zhu, Kelly D. Moynihan, Cary F. Opel, Nicole J. Yang, Naveen Mehta, Ryan L. Kelly, Gregory L. Szeto, Willem W. Overwijk, Darrell J. Irvine, K. Dane Wittrup (2016). Temporally Programmed CD8α+ DC Activation Enhances Combination Cancer Immunotherapy. Cell Reports. 17(10): 2503-2511. PMCID: PMC5204262 doi:10.1016/j.celrep.2016.11.020

Kelly D Moynihan, Cary F Opel, Gregory L Szeto, Alice Tzeng, Eric F Zhu, Jesse M Engreitz, Robert T Williams, Kavya Rakhra, Michael H Zhang, Adrienne M Rothschilds, Sudha Kumari, Ryan L Kelly, Byron H Kwan, Wuhbet Abraham, Kevin Hu, Naveen K Mehta, Monique J Kauke, Heikyung Suh, Jennifer R Cochran, Douglas A Lauffenburger, K Dane Wittrup, and Darrell J Irvine (2016). Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat. Med. PMCID: PMC5209798 doi:10.1038/nm.4200

Hok Hei Tam, Mariane B. Melo, Myungsun Kang, Jeisa M. Pelet, Vera M. Ruda, Maria H. Foley, Joyce K. Hue, Sudha Kumari, Jordan Crampton, Alexis D. Baldeon, Rogier W. Sanders, John P. Moore, Shane Crotty, Robert Langer, Daniel G. Anderson, Arup K. Chakraborty, and Darrell J. Irvine (2016). Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Proc. Natl. Acad. Sci. U.S.A. PMCID: PMC5086995 doi:10.1073/pnas.1606050113

Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR (2016). HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity. 45(3): 483–496. PMCID: PMC5040827 doi:10.1016/j.immuni.2016.08.016

Erin Janssen, Mira Tohme, Mona Hedayat, Marion Leick, Sudha Kumari, Narayanaswamy Ramesh, Michel J. Massaad, Sumana Ullas, Veronica Azcutia, Christopher C. Goodnow, Katrina L. Randall, Qi Qiao, Hao Wu, Waleed Al-Herz, Dianne Cox, John Hartwig, Darrell J. Irvine, Francis W. Luscinskas, Raif S. Geha (2016). A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J. Clin. Invest. PMCID: PMC5096816 doi:10.1172/JCI85774

Luke R. Doniusa, Yuxing Cheng, Jaewon Choi, Zhen-Yu J. Sun, Melissa Hanson, Michael Zhang, Todd M. Gierahn, Susanna Marquez, Mohammed Uduman, Steven H. Kleinstein, Darrell Irvine, J. Christopher Love, Ellis L. Reinherz, Mikyung Kim (2016). Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity. J. Virol. 90(19): 8875–8890. PMCID: PMC5021391 doi:10.1128/JVI.01089-16

R. Brad Jones, Stefanie Mueller, Rachel O’Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, Bruce D. Walker (2016). A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathogens, 12(4): e1005545. PMCID: PMC4833318 doi:10.1371/journal.ppat.1005545

Darrell J. Irvine (2016). A Receptor for All Occasions. Cell. 164(4): 599-600. doi:10.1016/j.cell.2016.01.030

Darrell J. Irvine (2016). Materializing the future of vaccines and immunotherapy. Nat. Rev. Mater. 1: 15008. doi:10.1038/natrevmats.2015.8

Kimmerling, R., Szeto, G. L., Li, J., Genshaft, A., Kazer, S., Borrajo, J., Blainey, P., Irvine, D. J., Shalek, A., Manalis, S.R. (2016). A microfluidic platform enabling single cell RNA-seq of multigenerational lineages. Nature Communications, 7. PMCID: PMC4729820 doi:10.1038/ncomms10220



Dane, E. L., & Irvine, D. J. (2015). Big thinking for adjuvants. Nature Biotechnology, 33(11), 1146–1148. doi:10.1038/nbt.3398

Arnold, K. B., Szeto, G. L., Alter, G., Irvine, D. J., & Lauffenburger, D. A. (2015). CD4+ T cell–dependent and CD4+ T cell–independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Science Signaling, 8(399), ra104. PMCID: PMC4634873 doi:10.1126/scisignal.aab0808
Featured on the cover:

Hotaling, N. A., Tang, L., Irvine, D. J., & Babensee, J. E. (2015). Biomaterial Strategies for Immunomodulation. Annual Review of Biomedical Engineering, 17(1), 317–349. PMCID: PMC4798784 doi:10.1146/annurev-bioeng-071813-104814

Darrell J. Irvine and Hidde Ploegh, "Editorial overview: Special section: Immunological engineering,"Current Opinion in Immunology, 35:ix–xi (2015). doi:10.1016/j.coi.2015.07.010

Irvine, D. J., Hanson, M. C., Rakhra, K., & Tokatlian, T. (2015). Synthetic Nanoparticles for Vaccines and Immunotherapy. Chemical Reviews, 115(19), 11109–11146. PMCID: PMC4688911 doi:10.1021/acs.chemrev.5b00109

B. Huang, W. D. Abraham, Y. Zheng, S. C. Bustamante López, S. S. Luo, D. J. Irvine, "Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells," Sci. Transl. Med. 7, 291ra94 (2015) PMCID: PMC4687972 doi:10.1126/scitranslmed.aaa5447
Cover story with a commentary: "Prescription for a pharmacyte" from Jeffrey Hubbell.

Prabhani Atukorale, Yu Sang Yang, Ahmet Bekdemir, Randy Carney, Paulo Silva, Nicki Watson, Francesco Stellacci and Darrell J. Irvine, "Influence of the Glycocalyx and Plasma Membrane Composition on Amphiphilic Gold Nanoparticle Association with Erythrocytes," Nanoscale(2015). PMCID: PMC6309694 doi:10.1039/c5nr01355k

Gregory Lee Szeto, Debra Van Egeren, Hermoon Worku, Armon Sharei, Brian Alejandro, Clara Park, Kirubel Frew, Mavis Brefo, Shirley Mao, Megan Heimann, Robert Langer, Klavs Jensen & Darrell J Irvine, "Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines," Scientific Reports 5:10276 (2015). PMCID: PMC4441198 doi:10.1038/srep10276

Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, and Irvine DJ, “Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants,”Journal of Clinical Investigation 125(6):2532-46 (2015). PMCID: PMC4497758 doi:10.1172/JCI79915

Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, and Wittrup KD, “Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2,” Cancer Cell 27(4):489–501 (2015). PMCID: PMC4398916 doi:10.1016/j.ccell.2015.03.004

Liu H and Irvine DJ, “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications,” Bioconjugate Chemistry 26(5):791-801 (2015). PMCID: PMC4694040 doi:10.1021/acs.bioconjchem.5b00103

Shenshen Wang,Jordi Mata-Fink,Barry Kriegsman, Melissa Hanson, Darrell J. Irvine, Herman N. Eisen, Dennis R. Burton, K. Dane Wittrup, Mehran Kardar, Arup K. Chakraborty. "Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies," Cell, 160 (4), 785-797, (2015). PMCID: PMC4357364 doi:10.1016/j.cell.2015.01.027

Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin. "Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway," eLife 2015;4:e04953 PMCID: PMC4355629 doi:10.7554/eLife.04953

Melissa C. Hanson, Wuhbet Abraham, Monica P. Crespo, Stephanie H. Chen, Haipeng Liu, Greg Lee Szeto, Mikyung Kim, Ellis L. Reinherz, Darrell J. Irvine, "Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides," Vaccine, 33 (7), 861-868, (2015). PMCID: PMC4312707 doi:10.1016/j.vaccine.2014.12.045



Yang Y-S, Carney RP, Stellacci F, and Irvine DJ, “Enhancing Radiotherapy by Lipid Nanocapsule-Mediated Delivery of Amphiphilic Gold Nanoparticles to Intracellular Membranes,” ACS Nano, 2014, 8 (9), pp 8992–9002. PMCID: PMC4194056 doi:10.1021/nn502146r

Jones RB, O’Connor R, Mueller S, Foley M, Szeto GS, Karel D, Lichterfeld M, Kovacs C, Ostroski MA, Tocha A, Irvine DJ, and Walker BD, “Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes,” PLoS Pathogens 10(8) e1004287 (2014). PMCID: PMC4133386 doi:10.1371/journal.ppat.1004287

Pejawar-Gaddy S, Kovacs JM, Barouch DH, Chen B, and Irvine DJ, “Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination,” Bioconjugate Chem., 2014, 25 (8), pp 1470–1478. PMCID: PMC4140538 doi:10.1021/bc5002246

Castellarnau M, Szeto GL, Su H-W, Tokatlian T, Love JC, Irvine DJ, and Voldman J “Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis,” Small 11(4):489-98 (2014). PMCID: PMC4303509 doi:10.1002/smll.201401369

Hanson MC, Bershteyn A, Crespo MP, and Irvine DJ, “Antigen Delivery by Lipid-enveloped PLGA Microparticle Vaccines Mediated by in situ Vesicle Shedding,” Biomacromolecules 15: 2475-2481 (2014). PMCID: PMC4115588 doi:10.1021/bm500337r

Liu H, Moynihan K, Zheng Y, Szeto G, Li A, Huang B, Egeren D, Park C, Irvine DJ. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 507(7493): 519–522 (2014). PMCID: PMC4069155 doi:10.1038/nature12978

Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, and Irvine DJ, "High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function," PLoS ONE 9(2):e87873 (2014). PMCID: PMC3923750 doi:10.1371/journal.pone.0087873

DeMuth PC, Min Y, Irvine DJ, and Hammond PT, "Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization," Advanced Healthcare Materials 3(1):47-58 (2014). PMCID: PMC3950936 doi:10.1002/adhm.201300139



DeMuth PC, Li AV, Abbink P, Liu J, Li H, Stanley KA, Smith KM, Lavine CL, Seaman MS, Kramer JA, Miller AD, Abraham W, Suh H, Elkhader J, Hammond PT, Barouch DH, and Irvine DJ, "Vaccine delivery with microneedle skin-patches in nonhuman primates," Nature Biotechnology 31 1082-1085 (2013). PMCID: PMC4011140.

Irvine DJ, Swartz MA, and Szeto GL, "Engineering synthetic vaccines using cues from natural immunity," Nature Materials 12(11) 978-990 (2013). PMCID: PMC3928825.

Li AV, Moon JJ, Abraham W, Suh H, Elkhader J, Seidman MA, Yen M, Im EJ, Foley MH, Barouch DH, and Irvine DJ, "Generation of effector memory T-cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination," Science Translational Medicine 5 204ra130 (2013). PMCID: PMC3934930.

Drake A, Joshi NS, Szeto GL, Zhu EF, Eisen HN, and Irvine DJ, "Koch Institute symposium on cancer immunology and immunotherapy," Cancer Immunology Research 1(4) 217-222 (2013). PMCID: PMC3897860.

Kim M, Song L, Moon J, Sun Z-YJ, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine DJ, and Reinherze E, "Immunogenicity of membrane-bound HIV-1 gp41 MPER segments is dominated by residue accessibility and modulated by stereochemistry," Journal of Biological Chemistry 288:31888-31901 (2013). PMCID: PMC3814781.

Van Lehn RC, Atukorale PU, Carney RP, Yang YS, Stellacci F, Irvine DJ, Alexander-Katz A (2013). "Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers." Nano Letters, 13:9 (2013). PMID: 23915118

Zheng Y, Stephan M, Gai SA, Abraham W, Shearer A, and Irvine DJ, "In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes," Journal of Controlled Release 172(2):426-35 (2013) . PMCID: PMC 4046900.

Su X, Yang N, Wittrup KD, and Irvine DJ, "Synergistic anti-tumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles," Biomacromolecules 14(4) 1093-1102 (2013). PMCID: PMC3646422.

Kwong B, and Irvine DJ, "Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity," Cancer Res. 73(5) 1547–58 (2013). PMCID: PMC3594475.

Ackerman M, Dugast A-S, McAndrew E, Tsoukas S, Licht A, Irvine DJ, and Alter G, "Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b" J. Virology 87(10):5468-76 (2013). PMCID: PMC3648186.

DeMuth PC, Min Y, Huang B, Kramer JA, Miller AD, Barouch DH, Hammond PT, and Irvine DJ, "Polymer multilayer tattooing for enhanced DNA vaccination," Nature Materials 12 367–376 (2013). PMCID: PMC3965298.

Wang Y and Irvine DJ, "Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes," Integrative Biology 5(3) 481-494 (2013). PMCID: PMC 3597436.

Mata-Fink J, Kriegsman B, Yu HX, Zhu H, Hanson MC, Irvine DJ, and Wittrup KD, "Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast," J. Mol. Biol. 425 444–456 (2013). PMCID: PMC 3785227.



Yamanaka YJ, Szeto GL, Gierahn TM, Forcier TL, Benedict KF, Brefo MSN, Lauffenburger DA, Irvine DJ, Love JC, "Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving," Anal. Chem. online (2012). PMCID: PMC3691955

DeMuth PC, Moon JJ, Suh H, Hammond PT, and Irvine DJ, "Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery," ACS Nano 6(9):8041-51 (2012). PMCID: PMC3475723.

DeMuth PC, Garcia-Beltran WF, Ai-Ling ML, Hammond PT, and Irvine DJ, "Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination," Adv. Funct. Mater. 23(2):161-172 (2012). PMCID: PMC3595545.

Stephan MT, Stephan S, Bak SP, Chen J, and Irvine DJ, "Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles," Biomaterials. 33(23) 5776-5787 (2012).

Moon JJ, Huang B, and Irvine DJ, "Engineering nano- and micro-particles to tune immunity," Advanced Materials. 24(28) 3724-3746 (2012).

Moon JJ, Suh H, Li AV, Ockenhouse CF, Yadava A, and Irvine DJ, "Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction," Proc. Natl. Acad. Sci., U.S.A. 109 1080-1085 (2012).

Moon JJ, Suh H, Polhemus ME, Ockenhouse CF, Yadava A, and Irvine DJ, "Antigen-displaying lipid-enveloped PLGA nanoparticles as delivery agents for a Plasmodium vivax malaria vaccine," PLoS ONE 7, e31472 (2012).

Bershteyn A, Hanson MC, Crespo MP, Moon JJ, Li AV, Suh H, and Irvine DJ, "Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine," Journal of Controlled Release 157 3543-365 (2012). PMCID: PMC3811132.

Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, and Stephanopoulos G, "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia," Nature 481, 380–384 (2012).


2011 and earlier

Jewell CM, Jung JM, Atukorale PU, Carney RP, Stellacci F, and Irvine DJ, "Oligonucleotide delivery by cell-penetrating "striped" nanoparticles," Angew. Chem. Intl. Ed. 50 12312-12315 (2011). PMID: 22028047

Jewell CM, Bustamante Lopez SC, and Irvine DJ, "In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles," Proc. Natl. Acad. Sci., U.S.A. 108(38) 15745-15750 (2011). PMCID: PMC3179077

Liu H, Kwong B, and Irvine DJ, "Membrane Anchored Immunostimulatory Oligonucleotides for in vivo Cell Modification and Localized Immunotherapy," Angew. Chemie Intl. Ed. 50 7052-7055 (2011). PMCID: PMC3166645

Kwong B, Liu H, and Irvine DJ, "Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy," Biomaterials 32(22) 5134-5147 (2011).

De Temmerman M-L, Rejman J, Demeester J, Irvine DJ, Gander B, and De Smedt SC, "Particulate vaccines: on the quest for optimal delivery and immune response," Drug Discovery Today 16 569-582 (2011).

Wang Y and Irvine DJ, "Engineering chemoattractant gradients using chemokine-releasing polysaccharide microspheres," Biomaterials 32(21) 4903-4913 (2011). PMCID: PMC3139910

Yoo J-W, Irvine DJ, Discher DE, and Mitragotri S, "Bio-inspired, bioengineering and biomimetic drug delivery carriers," Nature Reviews Drug Discovery 10(7) 521-535 (2011).

Stephan MT and Irvine DJ, "Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials," Nano Today 6 309-325 (2011). PMCID: PMC2935928

Su X, Fricke J, Kavanagh D, and Irvine DJ, "In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles," Molecular Pharmaceutics 8(3) 774-787 (2011).

Irvine DJ, Drug delivery: One nanoparticle, one kill. Nature Materials 10, 342–343 (2011). PMCID: PMC3842662.

Irvine DJ and Jewell CM, "Vaccine and Immunotherapy Delivery", in Comprehensive Biomaterials, Ed. P. Ducheyne, Elsevier Press (2011).

Martinez-Martin N, Fernandez-Arenas E, Cemerski A, Delgado P, Turner M, Neuser J, Irvine DJ, Huang B, Bustelo XR, Shaw A, and Alarcon B, "T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis," Immunity 35(2) 208-222 (2011). PMCID: PMC4033310.

Palmer MJ, Mahajan VS, Chen J, Irvine DJ, and Lauffenburger DA, "Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells," Immunology and Cell Biology 89(5) 581-594 (2011). **Highlighted as an Outstanding Observation by the journal.

Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM, "In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling," Biophysical Journal 100(8) 1893-1901 (2011). **Highlighted as a Featured Article by the journal.

Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Chiu W, and Irvine DJ, "Interbilayer-crosslinked multilamellar vesicles for potent humoral and cellular immune responses," Nature Materials 10(3) 243-251 (2011).

Ackerman ME, Moldt B., Wyatt, RT, Dugast A, McAndrew E, Tsoukas S, Jost S, Berger CT, Sciaranghella G, Liu Q, Irvine DJ, Burton DR, and Alter G, "A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples," Journal of Immunological Methods 366(1-2) 8-19 (2011).

DeMuth P, Su X, Samuel RE, Hammond PT, and Irvine DJ, "Nano-Layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA," Advanced Materials, 22(43) 4851-4856 (2010). (cover article)

Stephan M, Moon JJ, Um SH, Bershteyn A, and Irvine DJ, "Therapeutic cell engineering with surface-conjugated synthetic nanoparticles," Nature Medicine, 16(9) 1035-1041 (2010).

Atala A, Irvine DJ, Moses M, and Shaunak S, "Wound healing versus regeneration: Role of the tissue environment in regenerative medicine," MRS Bulletin 35(8) 597-606 (2010).

Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, and Weiss A, "Regulation of thymocyte positive selection and motility by GIT2," Nature Immunology 11(6) 503-11 (2010).

Swiston AJ, Gilbert JB, Irvine DJ, Cohen RE, and Rubner MF, "Freely suspended cellular "backpacks" lead to cell self-assembly," Biomacromolecules 11 1826-1832 (2010).

Hori Y, Stern PJ, Hynes RO, and Irvine DJ, "Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy," Biomaterials 30 6757-6767 (2009).

Su X, Kim BS, Kim SR, Hammond PT, and Irvine DJ, "Layer-by-Layer-Assembled multilayer films for transcutaneous drug and vaccine delivery," ACS Nano 3(11) 3719-3729 (2009).

Hu Y, Atukorale PU, Lu JJ, Moon JJ, Um SH, Cho EC, Wang Y, Chen J, and Irvine DJ, "Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles," Biomacromolecules,10 756-765 (2009). PMID: 19239276.

Maldonado RA, Soriano MA, Perdomo C, Sigrist K, Irvine DJ, Decker T, and Glimcher LH, "Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse," Journal of Experimental Medicine 206 877-892 (2009).

Hori Y, Winans AM, and Irvine DJ, "Modular injectable matrices based on alginate solution/microsphere mixtures that gel in situ and co-deliver immunomodulatory factors," Acta Biomaterialia 5 969-982 (2009). PMCID: PMC3042245.

Miller AC, Bershteyn A, Tan W, Hammond PT, Cohen RE, and Irvine DJ, "Block copolymer micelles as nanocontainers for controlled release of proteins from biocompatible oil phases," Biomacromolecules 10 732-741 (2009).

Hori Y, Winans AM, Huang CC, Horrigan EM, and Irvine DJ, "Injectable dendritic cell-carrying alginate gels for immunization and immunotherapy," Biomaterials 29 3671-3682 (2008).

Swiston AJ, Cheng C, Um SH, Irvine DJ, Cohen RE, and Rubner MF, "Surface functionalization of living cells with multilayer patches," Nano Letters 8 4446-4453 (2008).

Verma A, Uzun O, Hu Y, Watson N, Chen S, Irvine DJ, and Stellacci F, "Cell penetrating nanoparticles: the role of ligand shell structure," Nature Materials, 7 588-595 (2008). PMCID: PMC2684029

Bershteyn A, Chaparro J, Yau R, Kim M, Reinherz E, Ferreira-Moita L, and Irvine DJ, "Polymer-Supported lipid shells, onions, and flowers," Soft Matter 4 1787-1791 (2008). PMCID: PMC2743563

Miller AC, Bennett RD, Hammond, PT, Irvine DJ, and Cohen RE, "Functional nanocavity arrays via amphiphilic block copolymer thin films," Macromolecules 41(5) 1739-1744 (2008).

Irvine DJ, Stachowiak AN, and Y Hori, "Lymphoid tissue engineering: Invoking lymphoid tissue neogenesis in immunotherapy and models of immunity," Seminars in Immunology 20 137-146 (2008).

Stachowiak AN and Irvine DJ, "Inverse opal hydrogel-collagen composite scaffolds as a supportive microenvironment for immune cell migration," Journal of Biomedical Materials Research 85A 815-828 (2008).

Hu Y, Litwin T, Nagaraja AR, Kwong B, Katz J, Watson N, and Irvine DJ, "Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles," Nano Letters, 7(10); 3056-3064 (2007). [Abstract]

Irvine DJ, Doh J, and Huang B, "Patterned surfaces as tools to study ligand recognition and synapse formation by T cells," Current Opinion in Immunology 19 463-469, (2007).

Irvine DJ, Doh J, "Synthetic surfaces as artificial antigen presenting cells in the study of T cell receptor triggering and immunological synapse formation," Seminars in Immunology 19 245-254 (2007).

Stachowiak AN, Wang Y, Huang Y-C, and Irvine DJ, "Homeostatic lymphoid chemokines synergize with adhesion ligands to trigger T and B lymphocyte chemokinesis," The Journal of Immunology, 177(4) 2340-2348 (2006). [full text]

Doh J, and Irvine DJ, "Immunological Synapse Arrays: Patterned Protein Surfaces that Template Immunological Synapse Structure Formation in T Cells," J. Doh and D.J. Irvine, Proceedings of the National Academy of Sciences, U.S.A., 103(15) 5700-5705 (2006). [full text]

Kim H, Cohen RE, Hammond PT, and Irvine DJ, "Live Lymphocyte Arrays for Biosensing," Advanced Functional Materials, 16 1313-1323 (2006). [Abstract]

"Composition-tunable properties of amphiphilic comb copolymers containing protected methacrylic acid groups for multicomponent protein patterning," J.S. Katz, J. Doh, and D.J. Irvine, Langmuir 22 (1) 353-359 (2006). [Abstract] [PDF]

Bennett, R.D., Hart, A.J., Miller, A.C., Hammond, P.T., Irvine, D.J., and R.E. Cohen, "Creating patterned carbon nanotube catalysts through the microcontact printing of block copolymer micellar thin films," Langmuir 22(20) 8273-8276 (2006). [Abstract]

"Strategies for controlling the planar arrangement of block copolymer micelles and inorganic nanoclusters," R.D. Bennette, A.C. Miller, N.T. Kohen, P.T. Hammond, D.J. Irvine, and R.E. Cohen, Macromolecules 38 (26) 10728-10735 (2005). [Abstract] [PDF]

"Synthesis of protein-loaded hydrogel particles in an aqueous two-phase system for coincident antigen and CpG oligonucleotide delivery to antigen-presenting cells," S. Jain, W.T. Yap, and D.J. Irvine, Biomacromolecules 6 (5) 2590-2600 (2005). [Abstract] [PDF]

"beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization," J.R. Greenland, H.N. Liu, D. Berry, D.G. Anderson, W.K. Kim, D.J. Irvine, R. Langer, and N.L. Letvin, Molecular Therapy 12 (1) 164-170 (2005). [Abstract] [PDF]

"Directed cell migration via chemoattractants released from degradable microspheres," X. Zhao, S. Jain, B. Larman, S. Gonzalez, and D.J. Irvine, Biomaterials 26 (24) 5048-5063 (2005). [Abstract] [PDF]

"Bioactive hydrogels with an ordered cellular structure combine interconnected macroporosity and robust mechanical properties," A.N. Stachowiak, A. Bershteyn, and D.J. Irvine, Adv. Mater. 17 (4) 399 (2005).

"A role for the immunological synapse in lineage commitment of CD4 lymphocytes," R.A. Maldonado, D.J. Irvine, R. Schreiber, and L.H. Glimcher, Nature 431 527-532 (2004). [Abstract] [PDF]

"Photogenerated polyelectrolyte bilayers from an aqueous-processible photoresist for multiple protein patterning," J. Doh, and D.J. Irvine, J. Am. Chem. Soc., 126 (30) 9170-9171 (2004). [Abstract] [PDF]

"CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse," Q.J. Li, A.R. Dinner, S.Y. Qi, D.J. Irvine, J.B. Huppa, M.M. Davis, and A.K. Chakraborty, Nature Immunology , 5(8) 791-799 (2004). [Abstract] [PDF]

"T cell killing does not require the formation of a stable mature immunological synapse," M.A. Purbhoo, D.J. Irvine, J.B. Huppa , and M.M. Davis, Nature Immunology , 5 524-530 (2004). [Abstract] [PDF]

"Large Area Two-Dimensional B Cell Arrays for Sensing and Cell-Sorting Applications," H. Kim, J. Doh, D.J. Irvine, R.E. Cohen, and P.T. Hammond, Biomacromolecules , 5 822-827 (2004). [Abstract] [PDF]

"Function-specific variations in the immunological synapses formed by cytotoxic T cells," D.J. Irvine, Proc. Natl. Acad. Sci. USA 100 , 13739-13740 (2003). [Abstract] [PDF]

"Engineering biomaterials for control of immune cell functions," D.J. Irvine, A. Stachowiak, and S. Jain, Materials Science Forum , 426-4 3213-3218 (2003).

"Dynamics of cell surface molecules during T cell recognition," M.M.Davis, M. Krogsgaard, J.B.Huppa, C. Suman, M.A. Purbhoo, D.J. Irvine, L.C. Wu, and L. Ehrlich, Annual Review of Biochemistry , 72 712-742 (2003).  [Abstract] [PDF]

"Direct observation of ligand recognition by T cells," D.J. Irvine, M.A. Purbhoo, M. Krogsgaard, and M.M. Davis, Nature, 419(6909) 845-849 (2002). [Abstract] [PDF]

"Rapid signaling-induced receptor reorientation in the formation of the immunological synapse," W. Moss, D.J. Irvine, M. Krummel, and M.M. Davis, Proc. Natl. Acad. Sci. USA 99, 15024-15029 (2002). [Abstract] [PDF]

"Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus," Lily Y. Koo, D.J. Irvine, Anne M. Mayes, Douglas A. Lauffenburger, and Linda G. Griffith, J. Cell Sci. 115 1423-1433 (2002). [Abstract] [PDF]

"Simulations of Cell-Surface Integrin Binding to Nanoscale-Clustered Adhesion Ligands," D.J. Irvine, K.-A. Hue, A.M. Mayes, and L.G. Griffith, Biophys. J., 82(1) 120-132 (2002). [Abstract] [PDF]

"Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 2. Surface Segregation of Comb Polymers in Polylactide," D.J. Irvine, A.-V. Ruzette, A.M. Mayes, and L.G. Griffith, Biomacromolecules, 2(2) 545-556 (2001). [Abstract] [PDF]

"Nanoscale Clustering of RGD Peptides at Surfaces Using Comb Polymers. 1. Synthesis and Characterization of Comb Thin Films," D.J. Irvine, A.M. Mayes, and L.G. Griffith, Biomacromolecules, 2(1) 85-94 (2001). [Abstract] [PDF]

"Polymer Latexes for Cell-Resistant or Cell-Interactive Surfaces," P. Banerjee, D.J. Irvine, A.M. Mayes, and L.G. Griffith, J. Biomed. Mater. Res., 50(3) 331-339 (2000). [Abstract] [PDF]

"Tailored Polymer Surfaces for Controlled Cell Interactions," A.M. Mayes, D.J. Irvine, and L.G. Griffith, Mater. Res. Soc. Symp. Proc., 530, 73-84 (1998).

"Comparison of Tethered Star and Linear Poly(Ethylene Oxide) for Control of Biomaterials Surface Properties," D.J. Irvine, A.M. Mayes, S.K. Satija, J.G. Barker, S.J. Sofia-Allgor, and L.G. Griffith, Journal of Biomedical Materials Research, 40(3) 498-509 (1998). [Abstract] [PDF]

"Design of Biocompatible Surfaces," A.M. Mayes, D.G. Walton, D.J. Irvine, and L. Griffith, Amer. Chem. Soc. Proc. Div. Mat. Sci. Eng., 75, 78-79 (1996).

"Self-Consistent Field Analysis of Grafted Star Polymers," D.J. Irvine, A.M. Mayes, and L. Griffith-Cima, Macromolecules, 29(18) 6037-6043 (1996). [Abstract] [PDF]

"Computer Simulations of Self-Assembling Comb copolymers," D.J. Irvine, D. Gersappe, and A.C.Balazs, Langmuir, 11(10) 3848-3855 (1995). [Abstract] [PDF]

"The Use of Graft Copolymers to Bind Immiscible Blends," D. Gersappe, D. Irvine, A.C. Balazs, Y. Liu, J. Sokolov, M. Rafailovich, S. Schwarz, and D.G. Peiffer, Science, 265(5175) 1072-1074 (1994). [Abstract] [PDF]

"Contrasting the Compatibilizing Activities of Comb and Linear Copolymers," D. Gersappe, P.K. Harm, D. Irvine, and A.C. Balazs, Macromolecules, 27 (3) 720-724 (1994). [Abstract] [PDF]